Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Always Active
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.

No cookies to display.

Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.

No cookies to display.

Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.

No cookies to display.

 

Improve solubility within the gastrointestinal tract

Adare provides technologies to enable and improve the solubility of drugs with low solubility or an extreme pH-dependent solubility profile. The resulting formulations can offer effective oral dosing of poorly soluble drug candidates, equivalent therapy at lower doses, faster onset of action, and minimization of food effect. The solubility enhancement technologies provided by Adare include Diffucaps® solid solution or solid dispersion.

How It Works

A solid-solution/solid dispersion drug form is contained in layers of excipients and release-controlling polymers. This is combined with a crystallization inhibitor, enhancing bioavailability by maintaining the drug in its amorphous state. The solubility-enhanced beads can be coated with one or more functional polymers to achieve extended-release profiles suitable for once- or twice-daily dosing.

Our innovative solubility enhancement technologies provide:

  • Substantial global experience in all aspects
  • Effective oral dosing of poorly soluble drug candidates
  • Equivalent therapy at lower doses
  • Faster onset of action
  • Minimization of food effect
  • Adjustable dosage strength and dissolution profile to achieve the desired in vivo pharmacokinetic profile
  • Enhanced drug solubility in sections of the gastrointestinal tract through combined use with other Adare technologies

Solubility Enhancement Technologies

  • Bench-to-pilot scale Spray-drying
  • Hot Melt (Leistritz ZSE 18)
  • Dyno-mill
  • Diffucaps
  • Conventional approaches using:
  • Cyclodextrins
    • Solubilizers
    • Surfactants
    • Super-disintegrants

Speak With An Expert

Profile Photo: Nathan Dormer

Nathan Dormer

Director, Drug Product Development

Nathan Dormer, Ph.D., is the Director of Drug Product Development at Adare Pharma Solutions and is responsible for pharmaceutical development activities at Adare’s Lenexa, KS and Philadelphia, PA facilities, where he supports a team of formulation scientists and analysts. He is a pharmaceutical scientist and bioengineer by training, with more than 16 years of experience developing microsphere-based solid oral and parenteral/implantable dosage forms in academic, innovator, and CDMO settings. Dr. Dormer earned his B.S. in Chemical Engineering and his Ph.D. (w/Honors) in Bioengineering from The University of Kansas while receiving NIH-sponsored Pharmaceutical Biotech Training.

Contact Me

What question can I answer for you?

"*" indicates required fields

Personal details

Company

Let us know how we can help

0 of 1000 max characters
By ticking this box, you acknowledge and agree to our GDPR compliance and privacy policy*
opt-in for SMS marketing
This field is hidden when viewing the form
This field is hidden when viewing the form
This field is hidden when viewing the form
This field is hidden when viewing the form
This field is hidden when viewing the form
This field is hidden when viewing the form